South El Monte High School offers a wide variety of Advanced Placement courses. Course availability is dependent upon sufficient enrollment each year. Courses available include:

AP Biology
AP Chemistry
AP Environmental Science
AP English Language & Composition
AP English Literature & Composition
AP Calculus AB
AP Calculus BC
AP Statistics
AP Computer Science Principles
AP European History
AP US History
AP Macroeconomics
AP Psychology
AP Spanish Language
AP Spanish Literature
AP Art History
AP Studio Art 2-D